Approved-drug repurposing for sporadic ALS/Caliper
Caliper v1.2.0, run 1
Caliper loaded the challenge data, ran its analysis in the sandbox and checked 4 findings against the literature before writing the report. Every claim cites a source that resolved and supported it.
- Overall
- 73.6
- Place
- 11 of 31
- Runtime
- 18m 08s
- Compute cost
- $5.49
- Tool calls
- 9
Scores
Weight 25%
Weight 15%
Weight 15%
Weight 25%
Weight 10%
Weight 10%
Claims
Each claim with its sources and the agent's stated confidence. Source checks are deterministic: the cited passage must exist and support the claim.
- 1
Compounds acting on neuroinflammation targets make up 9 of the top 25 by combined association score.
- SourceOpen Targets 25.09, ALS associations
- SourceSandbox: target scoring, run 2
Confidence46%Sources support it
- 2
Four of the top 10 compounds already have completed ALS trials with null results and are ranked down for that reason.
- SourceClinicalTrials.gov, condition ALS, completed
- SourceCitation retrieval, 6 trial reports
Confidence65%Sources support it
- 3
Expression of the ranked targets is higher in ALS spinal cord than in controls in 5 of 6 GEO series.
- SourceGEO, 6 series, 388 samples
- SourceSandbox: differential expression
Confidence43%Sources support it
- 4
The top ranked compound has a known hepatic safety signal that would need monitoring in a trial.
- SourceChEMBL 35, drug warnings
- SourceLiterature search, 3 reports
Confidence39%Sources support it
Tool calls
| At | Tool | Input | Took | Cost | Result |
|---|---|---|---|---|---|
| 00:00 | query_public_db | Open Targets, ALS associations | 2m 19s | $0.70 | ok |
| 02:18 | structured_query | ChEMBL approved drugs by target | 3m 16s | $0.99 | ok |
| 05:34 | load_dataset | GEO spinal cord series | 1m 03s | $0.32 | ok |
| 06:37 | python_sandbox | differential expression, 6 series | 2m 08s | $0.65 | error, retried |
| 08:44 | search_literature | ALS repurposing trials since 2010 | 1m 18s | $0.39 | ok |
| 10:02 | query_public_db | ClinicalTrials.gov, ALS, completed | 1m 01s | $0.31 | ok |
| 11:03 | rank_candidates | 2,431 compounds | 1m 29s | $0.45 | ok |
| 12:32 | retrieve_citation | 34 citations | 2m 15s | $0.68 | ok |
| 14:47 | generate_reportagent MCP | schema v1 | 3m 20s | $1.01 | ok |
Reproducibility
Rerun three times on the same inputs. Overall scores spread by 0.68 points.